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1

The Wittig and Related Reactions in Natural Product Synthesis

K. C. Nicolaou, Michael W. Härter, Janet L. Gunzner, Alan Nadin

Journal:

European Journal of Organic Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 2.16 MB

english, 1997

2

10.1038/32623

Nicolaou, K. C., Yang, Zhen, Shi, Guo-qiang, Gunzner, Janet L., Agrios, Konstantinos A., Gärtner, Peter

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 352 KB

english, 1998

3

Total Synthesis of Brevetoxin A: Part 3: Construction of GHIJ and BCDE Ring Systems

K. C. Nicolaou, Guo-qiang Shi, Janet L. Gunzner, Peter Gärtner, Paul A. Wallace, Michael A. Ouellette, Shuhao Shi, Mark E. Bunnage, Konstantinos A. Agrios, Chris A. Veale, Chan-Kou Hwang, John Hutchin

Journal:

Chemistry - A European Journal

Année:

1999

Langue:

english

Fichier:

PDF, 407 KB

english, 1999

4

Total Synthesis of Brevetoxin A: Part 2: Second Generation Strategy and Construction of EFGH Model System

K. C. Nicolaou, Paul A. Wallace, Shuhao Shi, Michael A. Ouellette, Mark E. Bunnage, Janet L. Gunzner, Konstantinos A. Agrios, Guo-qiang Shi, Peter Gärtner, Zhen Yang

Journal:

Chemistry - A European Journal

Année:

1999

Langue:

english

Fichier:

PDF, 252 KB

english, 1999

5

Total Synthesis of Brevetoxin A: Part 1: First Generation Strategy and Construction of BCD Ring System

K. C. Nicolaou, Mark E. Bunnage, Daniel G. McGarry, Shuhao Shi, Patricia K. Somers, Paul A. Wallace, Xin-Jie Chu, Konstantinos A. Agrios, Janet L. Gunzner, Zhen Yang

Journal:

Chemistry - A European Journal

Année:

1999

Langue:

english

Fichier:

PDF, 470 KB

english, 1999

6

Total Synthesis of Brevetoxin A: Part 4: Final Stages and Completion

K. C. Nicolaou, Janet L. Gunzner, Guo-qiang Shi, Konstantinos A. Agrios, Peter Gärtner, Zhen Yang

Journal:

Chemistry - A European Journal

Année:

1999

Langue:

english

Fichier:

PDF, 318 KB

english, 1999

7

Callipeltoside A: Assignment of Absolute and Relative Configuration by Total Synthesis

Barry M. Trost, Olivier Dirat, Janet L. Gunzner

Journal:

Angewandte Chemie

Année:

2002

Langue:

english

Fichier:

PDF, 78 KB

english, 2002

8

Callipeltoside A: Assignment of Absolute and Relative Configuration by Total Synthesis

Barry M. Trost, Olivier Dirat, Janet L. Gunzner

Journal:

Angewandte Chemie International Edition

Année:

2002

Langue:

english

Fichier:

PDF, 78 KB

english, 2002

9

Kupfer(I)-unterstützte Stille-Kupplung von α-stannylsubstituierten Enolethern mit Enoltriflaten: Aufbau von komplexen Polyethergerüsten

Prof. Dr. Kyriacos Costa Nicolaou, Mitsunobu Sato, Neil D. Miller, Janet L. Gunzner, Johanne Renaud, Edouard Untersteller

Journal:

Angewandte Chemie

Année:

1996

Fichier:

PDF, 496 KB

1996

10

Copper(I)-Promoted Stille Cross-Coupling of Stannyl Enol Ethers with Enol Triflates: Construction of Complex Polyether Frameworks

Prof. Dr. K. C. Nicolaou, Mitsunobu Sato, Dr. Neil D. Miller, Janet L. Gunzner, Dr. Johanne Renaud, Dr. Edouard Untersteller

Journal:

Angewandte Chemie International Edition

Année:

1996

Langue:

english

Fichier:

PDF, 300 KB

english, 1996

11

ChemInform Abstract: Palladium-Catalyzed Functionalization of Lactones via Their Cyclic Ketene Acetal Phosphates. Efficient New Synthetic Technology for the Construction of Medium and Large Cyclic Ethers.

K. C. NICOLAOU, G.-Q. SHI, J. L. GUNZNER, P. GAERTNER, Z. YANG

Journal:

Année:

1997

Fichier:

PDF, 35 KB

1997

12

ChemInform Abstract: The Wittig and Related Reactions in Natural Product Synthesis

K. C. NICOLAOU, M. W. HAERTER, J. L. GUNZNER, A. NADIN

Journal:

Année:

1997

Fichier:

PDF, 24 KB

1997

13

ChemInform Abstract: New Synthetic Technology for the Construction of 9-Membered Ring Cyclic Ethers. Construction of the EFGH Ring Skeleton of Brevetoxin A.

K. C. NICOLAOU, Z. YANG, M. OUELLETTE, G.-Q. SHI, P. GAERTNER, J. L. GUNZNER, K. A. AGRIOS, R. HUBER, R. CHADHA, D. H. HUANG

Journal:

Année:

1997

Fichier:

PDF, 29 KB

1997

14

ChemInform Abstract: Total Synthesis of Brevetoxin A

K. C. NICOLAOU, Z. YANG, G. SHI, J. L. GUNZNER, K. A. AGRIOS, P. GAERTNER

Journal:

Année:

1998

Fichier:

PDF, 24 KB

1998

15

ChemInform Abstract: Total Synthesis of Brevetoxin A. Part 4. Final Stages and Completion.

K. C. Nicolaou, Janet L. Gunzner, Guo-qiang Shi, Konstantinos A. Agrios, Peter Gaertner, Zhen Yang

Journal:

Année:

1999

Fichier:

PDF, 26 KB

1999

16

ChemInform Abstract: Total Synthesis of Brevetoxin A. Part 2. Second Generation Strategy and Construction of EFGH Model System.

K. C. Nicolaou, Paul A. Wallace, Shuhao Shi, Michael A. Ouellette, Mark E. Bunnage, Janet L. Gunzner, Konstantinos A. Agrios, Guo-qiang Shi, Peter Gaertner, Zhen Yang

Journal:

Année:

1999

Fichier:

PDF, 28 KB

1999

17

ChemInform Abstract: Total Synthesis of Brevetoxin A. Part 1. First Generation Strategy and Construction of BCD Ring System.

K. C. Nicolaou, Mark E. Bunnage, Daniel G. McGarry, Shuhao Shi, Patricia K. Somers, Paul A. Wallace, Xin-Jie Chu, Konstantinos A. Agrios, Janet L. Gunzner, Zhen Yang

Journal:

Année:

1999

Fichier:

PDF, 30 KB

1999

18

ChemInform Abstract: An Unusual Regioselectivity in the Pd-Catalyzed Cross Coupling of Alkynes. A Correction.

Barry M. Trost, Janet L. Gunzner, Tatsuro Yasukata

Journal:

Année:

2001

Fichier:

PDF, 33 KB

2001

19

ChemInform Abstract: Total Synthesis of Deschlorocallipeltoside A.

Barry M. Trost, Janet L. Gunzner

Journal:

Année:

2002

Fichier:

PDF, 25 KB

2002

20

ChemInform Abstract: Callipeltoside A: Assignment of Absolute and Relative Configuration by Total Synthesis.

Barry M. Trost, Olivier Dirat, Janet L. Gunzner

Journal:

Année:

2002

Fichier:

PDF, 26 KB

2002

21

GDC-0449—A potent inhibitor of the hedgehog pathway

Kirk D. Robarge, Shirley A. Brunton, Georgette M. Castanedo, Yong Cui, Michael S. Dina, Richard Goldsmith, Stephen E. Gould, Oivin Guichert, Janet L. Gunzner, Jason Halladay, Wei Jia, Cyrus Khojasteh,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 2.02 MB

english, 2009

22

Corrigendum to “GDC-0449—A potent inhibitor of the hedgehog pathway” [Bioorg. Med. Chem. Lett. 19 (2009) 5576]

Kirk D. Robarge, Shirley A. Brunton, Georgette M. Castanedo, Yong Cui, Michael S. Dina, Richard Goldsmith, Stephen E. Gould, Oivin Guichert, Janet L. Gunzner, Jason Halladay, Wei Jia, Cyrus Khojasteh,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 109 KB

english, 2010

23

Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor

Timothy P. Heffron, Megan Berry, Georgette Castanedo, Christine Chang, Irina Chuckowree, Jennafer Dotson, Adrian Folkes, Janet Gunzner, John D. Lesnick, Cristina Lewis, Simon Mathieu, Jim Nonomiya, Al

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1001 KB

english, 2010

24

Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway

Georgette M. Castanedo, Shumei Wang, Kirk D. Robarge, Elizabeth Blackwood, Daniel Burdick, Christine Chang, Gerrit J.P. Dijkgraaf, Stephen Gould, Janet Gunzner, Oivin Guichert, Jason Halladay, Cyrus K

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 455 KB

english, 2010

25

An unusual regioselectivity in the Pd-catalyzed cross coupling of alkynes. A correction

Barry M Trost, Janet L Gunzner, Tatsuro Yasukata

Journal:

Tetrahedron Letters

Année:

2001

Langue:

english

Fichier:

PDF, 121 KB

english, 2001

26

Identification and synthesis of [1,2,4]triazolo[3,4-a]phthalazine derivatives as high-affinity ligands to the α2δ-1 subunit of voltage gated calcium channel

Alec D. Lebsack, Janet Gunzner, Bowei Wang, Richard Pracitto, Hervé Schaffhauser, Angelina Santini, Jayashree Aiyar, Robert Bezverkov, Benito Munoz, Wensheng Liu, Shankar Venkatraman

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 289 KB

english, 2004

27

10.1038/326233b0

Nicolaou, K. C., Yang, Zhen, Shi, Guo-qiang, Gunzner, Janet L., Agrios, Konstantinos A., Gärtner, Peter

Journal:

Année:

1987

Fichier:

PDF, 169 KB

1987

28

Callipeltoside A: Total Synthesis, Assignment of the Absolute and Relative Configuration, and Evaluation of Synthetic Analogues

Trost, Barry M., Gunzner, Janet L., Dirat, Olivier, Rhee, Young H.

Journal:

Journal of the American Chemical Society

Année:

2002

Langue:

english

Fichier:

PDF, 407 KB

english, 2002

29

Discovery of Selective LRRK2 Inhibitors Guided by Computational Analysis and Molecular Modeling

Chen, Huifen, Chan, Bryan K., Drummond, Jason, Estrada, Anthony A., Gunzner-Toste, Janet, Liu, Xingrong, Liu, Yichin, Moffat, John, Shore, Daniel, Sweeney, Zachary K., Tran, Thuy, Wang, Shumei, Zhao,

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 3.16 MB

english, 2012

30

ChemInform Abstract: Copper(I)-Promoted Stille Cross-Coupling of α-Stannyl Enol Ethers with Enol Triflates: Construction of Complex Polyether Frameworks.

K. C. NICOLAOU, M. SATO, N. D. MILLER, J. L. GUNZNER, J. RENAUD, E. UNTERSTELLER

Journal:

Année:

1996

Fichier:

PDF, 32 KB

1996

31

Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer

Sutherlin, Daniel P., Bao, Linda, Berry, Megan, Castanedo, Georgette, Chuckowree, Irina, Dotson, Jenna, Folks, Adrian, Friedman, Lori, Goldsmith, Richard, Gunzner, Janet, Heffron, Timothy, Lesnick, Jo

Journal:

Journal of Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 3.50 MB

english, 2011

32

Rational Design of Phosphoinositide 3-Kinase α Inhibitors That Exhibit Selectivity over the Phosphoinositide 3-Kinase β Isoform

Heffron, Timothy P., Wei, BinQing, Olivero, Alan, Staben, Steven T., Tsui, Vickie, Do, Steven, Dotson, Jennafer, Folkes, Adrian J., Goldsmith, Paul, Goldsmith, Richard, Gunzner, Janet, Lesnick, John,

Journal:

Journal of Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 2.42 MB

english, 2011

33

Potent and Selective Aminopyrimidine-Based B-Raf Inhibitors with Favorable Physicochemical and Pharmacokinetic Properties

Mathieu, Simon, Gradl, Stefan N., Ren, Li, Wen, Zhaoyang, Aliagas, Ignacio, Gunzner-Toste, Janet, Lee, Wendy, Pulk, Rebecca, Zhao, Guiling, Alicke, Bruno, Boggs, Jason W., Buckmelter, Alex J., Choo, E

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 4.52 MB

english, 2012

34

Fragment-Based Identification of Amides Derived from trans -2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)

Giannetti, Anthony M., Zheng, Xiaozhang, Skelton, Nicholas J., Wang, Weiru, Bravo, Brandon J., Bair, Kenneth W., Baumeister, Timm, Cheng, Eric, Crocker, Lisa, Feng, Yezhen, Gunzner-Toste, Janet, Ho, Y

Journal:

Journal of Medicinal Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 1.96 MB

english, 2014

35

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

Lauffer, B. E. L., Mintzer, R., Fong, R., Mukund, S., Tam, C., Zilberleyb, I., Flicke, B., Ritscher, A., Fedorowicz, G., Vallero, R., Ortwine, D. F., Gunzner, J., Modrusan, Z., Neumann, L., Koth, C. M

Journal:

Journal of Biological Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 6.52 MB

english, 2013

36

Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties

Gunzner-Toste, Janet, Zhao, Guiling, Bauer, Paul, Baumeister, Timm, Buckmelter, Alexandre J., Caligiuri, Maureen, Clodfelter, Karl H., Fu, Bang, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Liang, Xia

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 3.58 MB

english, 2013

37

Total Synthesis of Deschlorocallipeltoside A

Trost, Barry M., Gunzner, Janet L.

Journal:

Journal of the American Chemical Society

Année:

2001

Langue:

english

Fichier:

PDF, 48 KB

english, 2001

38

New Synthetic Technology for the Construction of 9-Membered Ring Cyclic Ethers. Construction of the EFGH Ring Skeleton of Brevetoxin A

Nicolaou, K. C., Yang, Z., Ouellette, M., Shi, G.-Q., Gärtner, P., Gunzner, J. L., Agrios, K. A., Huber, R., Chadha, R., Huang, D. H.

Journal:

Journal of the American Chemical Society

Année:

1997

Langue:

english

Fichier:

PDF, 179 KB

english, 1997

39

Palladium-Catalyzed Functionalization of Lactones via Their Cyclic Ketene Acetal Phosphates. Efficient New Synthetic Technology for the Construction of Medium and Large Cyclic Ethers

Nicolaou, K. C., Shi, G.-Q., Gunzner, J. L., Gärtner, P., Yang, Z.

Journal:

Journal of the American Chemical Society

Année:

1997

Langue:

english

Fichier:

PDF, 146 KB

english, 1997

40

Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Non-Cleavable Drug-Linkers

Gregson, Stephen J., Masterson, Luke A., Wei, Binqing, Pillow, Thomas H., Spencer, Susan D., Kang, Gyoung-Dong, Yu, Shang-Fan, Raab, Helga, Lau, Jeffrey, Li, Guangmin, Lewis Phillips, Gail D., Gunzner

Journal:

Journal of Medicinal Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.69 MB

english, 2017

41

Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity

Wei, Binqing, Gunzner-Toste, Janet, Yao, Hui, Wang, Tao, Wang, Jing, Xu, Zijin, Chen, Jinhua, Wai, John, Nonomiya, Jim, Tsai, Siao Ping, Cruz-Chuh, Josefa dela, Kozak, Katherine Ruth, Liu, Yichin, Yu,

Journal:

Journal of Medicinal Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.77 MB

english, 2017